What takes us out of the presence of God?

Isaiah 59:2 But your iniquities [literal: not wanting to submit to God] have separated you from your God; And your sins have hidden His face from you.

You need to understand that sin is failing to attain to the glory of God. 

Rebelliousness against God does separate you from God.  Even after you are born again, a rebellious attitude is as the sin of witchcraft.  It is an abomination.  It will separate from God.  Eventually, a person who is rebellious will turn to his or her own flesh, own self, for answers, and those answers will seem to be right but they will be wrong.  They will seem to be helpful, but they will have a final result of destruction.  They will seem righteous, but they will be shown to be self-righteous.

You can be one of those who is saved.

Click to understand how you can be born again?