The underlying genetic mechanism of evolution is random mutation, and specifically mutation that is beneficial to life. Biology textbooks in theory present positive and negative mutations to students as though these were commonplace and roughly equal in number. However, these books fail to inform students that unequivocally positive mutations are unknown to genetics, since they have never been observed (or are so rare as to be irrelevant). ~ Dr. Barney Maddox

The biology textbooks in other chapters teach that most mutations are pathologic, or disease-causing, but they don't apply that information to evolution. The worst diseases doctors treat today are caused by genetic mutations. ~ Dr. Barney Maddox

Virtually all the "beneficial mutations" known are only equivocally beneficial, not unequivocally beneficial. In bacteria, several mutations in cell wall proteins may deform the proteins enough so that antibiotics cannot bind to the mutant bacteria. This creates bacterial resistance to that antibiotic. Does this support evolutionary genetic theory? No, since the mutant bacteria do not survive as well in the wild as the native (non-mutant) bacteria. ~ Dr. Barney Maddox

In humans there is one equivocally beneficial mutation, out of 4,000 devastating mutations: sickle cell anemia.... Without medical support the homozygotes [people with sickle cell anemia] are likely to die in young to middle age.  But there is one positive. Heterozygotes in Africa, where malaria is endemic, are more resistant to malaria...  ~ Dr. Barney Maddox

According to evolution, all genes that are expressed are merely mutations. Actually, the expression, not just the latency, of all our genes is positive when expressed. Sickling is always negative when it occurs, so it remains a very poor example of evolution, and in fact refutes it. Evolution theorists have yet to demonstrate the unequivocally positive nature of a single mutation.   ~ Dr. Barney Maddox

Harmful mutations destroy the individual organism, preventing the gene from being passed on. The "neutral mutations" will ultimately destroy entire species, because the mutated genes will be passed on and accumulate.  ~ Dr. Barney Maddox

Random changes occur every day that destroy the manufacture and function of machines. Likewise, random changes to information destroy the function and outcome of that information. ~ Dr. Barney Maddox

In the twentieth century many genetic researchers tried to "accelerate evolution" by increasing mutation rates.12 This can be accomplished with ionizing radiation, like x-rays, or chemical mutagens. Researchers gave plants and fruit flies very high doses of radiation or other mutagens in hopes that new life forms, or at least improved organs, would result. Decades of this type of research resulted in repeated failure. Every mutation observed was deleterious to the organisms' survival. ~ Dr. Barney Maddox

Carl Sagan, in his Cosmos program "One Voice in the Cosmic Fugue," stated that evolution was caused by "the slow accumulations of favorable mutations." While this may be the current popular theory, real science disagrees. The perpetuation of the Darwin myth clashes with reality--the God-created reality--where living things and their genomes were created "very good" and have degenerated from there. Genetic science demonstrates that the absolutely essential ingredient for the origin of life is an infinite Intelligence. Of all the origin stories, only one contains this essential ingredient--Genesis 1. ~ Dr. Barney Maddox

"Read John Sanford's book Genetic Entropy and the Mystery of the Genome and wonder how intelligent people could ever bring themselves to believe that mutations would create progress in fitness, and continue to believe natural selection built all the wonders of life, decades after it was demonstrated by evolution-believing secular population geneticists to be unworkable."  (Source: CREV - read more)